Pharmacokinetic Simulator

Model drug concentration over time using standard first-order kinetics. Visualize accumulation, steady-state, and washout phases.

Simulation Parameter

Dose Amount

Dosing Interval (Hours)

Topical gel daily = 24h. EOD Injection = 48h.

Half-Life (Hours)

Simulation Window (Hours)

Steady-State Simulator

Understand how regular dosing leads to accumulation and steady-state levels.

Model Assumptions:
Assumes consistent dosing interval, identical dose amounts, and immediate absorption (IV bolus model) to simplify steady-state concepts.

Concentration Profile

Concentration

Steady State Target

Accumulation Ratio

2.00x

Due to overlapping doses

Time to Steady State

120h

~5 Half-Lives

Peak (Steady State)

200.0

Fluctuation

67%

(Peak - Trough) / Avg

Clinical Interpretation

Steady State: Achieved approximately at 120 hours (5x half-lives).

Accumulation: Moderate to low accumulation (2.0x). Dosing interval allows substantial clearance.

Fluctuation: Moderate fluctuation (67%). Standard for many short half-life compounds.